'Antidoting' And 'Deactivating' Of Potentized Homeopathic Drugs- A Scientific Explanation:
In Chronic Diseases : Para 142, Hahnemann describes the articles to be avoided during homeopathic treatment:
“For many easily perceived reasons, but especially in order that this delicate doses of medicine may not be interfered with in their action, the homoeopathic physician cannot in his antipsoric treatment allow the intermediate use of any hitherto customary domestic remedy, no perfumery of any kind, no fragrant extracts, no smelling-salts, no Baldwin tea, or any other herb teas, no peppermint confection, no spiced confections or anise-sugar or stomach drops, or liqueurs, no Iceland-moss, or spiced chocolate, no spice-drops, tooth-tinctures or tooth-powders of the ordinary kinds, nor any of the other articles of luxury.”
According to this statement of hahnemann, , the ‘delicate doses of medicine’ used in homeopathy may be ‘interfered with in their actions’ by "customary domestic remedy", "perfumery", "fragrant" "smelling-salts", "Baldwin tea", "herb teas", "peppermint confection", "spiced confections", "anise-sugar" , "liqueurs", "Iceland-moss", "spiced chocolate", "spice-drops", "tooth-tinctures" "tooth-powders" etc. Kindly notice, most of the articles Hahnemann listed here are those which may contain VOLATILE OILS. That indicates a very important observation.
I have been wondering for long whether there exist any scientific basis for this advice made by Hahnemann. After studying the molecular structure of various volatile organic compounds including CAMPHOR, and understanding the mechanism of their interactions, now I think there could be some amount of truth in it, though it was somewhat distorted and far-stretched by hahnemann. Certain chemical molecules contained in these aromatic organic compounds may be capable of antidoting certain MOLECULAR IMPRINTS contained in a wide class of potentized homeopathic drugs- especially drugs of vegetable origin-, by deactivating their constituent molecular imprints by binding to them due to their conformational affinity.
Most aromatic organic compounds have a C=O moiety in its functional group. Such compounds are called carbonyl compounds, which also include aldehydes, ketones, carboxylic acid, esters, amides, enones, acyl halides, acid unhydrides etc. Most of these substances are aroma compounds, which are responsible for the property known as fragrance and flavors.
Compounds that contain C-O bonds possess differing reactivity based upon the location and hybridization of the C-O bond, owing to the electron-withdrawing effect of hybridized oxygen. Certain medicinal properties of various vegetable substances and some animal products are mostly due to the presence of molecules having highly reactive C=O moiety in their functional groups.
In organic chemistry, functional groups are specific groups of atoms within molecules that are responsible for the characteristic chemical reactions of those molecules. The same functional group will undergo the same or similar chemical reactions regardless of the size of the molecule it is a part of. However, its relative reactivity can be modified by nearby functional groups.
The word moiety is often used synonymously to “functional group,” but to be more specific, a moiety is a part of a molecule that may include either whole functional groups or a parts of functional groups as substructures. The atoms of functional groups are linked to each other and to the rest of the molecule by covalent bonds. When the group of covalently bound atoms bears a net charge, the group is referred to more properly as a polyatomic ion or a complex ion. Any subgroup of atoms of a compound also may be called a radical, and if a covalent bond is broken homolytically, the resulting fragment radicals are referred as free radicals.
Camphor is a volatile organic aroma compound with chemical formula C10H16O, belonging to the class known as terpenoids. When kept open, its molecules would easily diffuse into the atmosphere.
Camphor is a cyclic terpene, having a C=O moeity in its functional group. Such compounds are called carbonyl compounds, which also include aldehydes, ketones, carboxylic acid, esters, amides, enones, acyl halides, acid unhydrides etc. Most of these substances are aroma compounds, which are responsible for the property known as fragrance and flavors. Compounds that contain C-O bonds each possess differing reactivity based upon the location and hybridization of the C-O bond, owing to the electron-withdrawing effect of sp hybridized oxygen.Medicinal properties of various vegetable substances and some animal products are mostly due to the presence of molecules having highly reactive C=O moiety in their functional groups.
Drug molecules act upon the biological molecules in the organism by binding their functional groups to specific active groups on the complex biological molecules. Here, the functional groups of drug molecules called ligands, and the biological molecules are called targets. Ligand-target intercation is always determined by a ‘key-lock’ relationship due to complementary configurational affinities.
It is to be specifically noted that same functional group will undergo the same or similar chemical reactions regardless of the size or configuration of of the molecule it is a part of. However, its relative reactivity can be modified by nearby functional groups known as facilitating groups. That means, different types of drug molecules or pathogenic molecules having same functional groups and facilitating groups can bind to same biological molecules, and produce similar molecular inhibitions and symptoms.
Homeopathic principle of ‘similimum’ is well explained by this understanding. If a drug molecule can produce symptoms similar to symptoms of a particular disease, it means that the drug molecule and disease causing molecule has same functional groups on them. Obviously, similarity of symptoms means similarity of functional groups of pathogenic molecules and drug molecules. To be similimum, the whole molecules need not be similar, but similarity of functional groups is enough.
Potentized drugs would contain the molecular imprints of drug molecules, along with molecular imprints of their functional groups. These molecular imprints will have specific configurational affinity towards any molecule having same functional groups, and can bind and deactivate them.
As said above, most of the vegetable and animal drugs contains diverse types of aromatic drug molecules and esters having C=O functional groups, which are also present on camphor molecules. Potentized homeopathic drugs would contain molecular imprints of this functional groups, which can be easily deactivated by crude camphor molecules as well as other aromatic molecules. Molecules of Volatile substances such as camphor would easily diffuse into atmosphere and nearby potentized drugs, and bind to molecular imprints of C=O functional groups they contain. It would result in deactivation of molecular imprints, which we call antidoting.
I hope, I have scientifically explained the molecular mechanism of the phenomenon of antidoting of potentized drugs by perfumes and strong smelling substances. Most perfumes contains esters, which have C=O functional groups.
Now it is obvious that CAMPHOR IS NOT A UNIVERSAL ANTIDOTE AS WE BELIEVE. Only MOLECULAR or crude forms and low potencies of CAMPHOR can ‘selectively’ antidote particular ‘molecular imprints’ contained in potentized drugs.
MOLECULAR IMPRINTS or or potencies above 12c of camphor cannot antidote any other potentized drugs. More over, even MOLECULAR forms of camphor cannot antidote ALL molecular imprints of potentized drugs, but only those individual molecular imprints which have conformational affinity due to the presence of C=O functional groups.
Drug relationship is a subject about which most homeo practitioners are very much worried and confused. Some practitioners very much rely upon ‘drug relationships’ even in deciding their treatment protocols. Concepts such as ‘complementary’, ‘inimical’, ‘antidotal’ etc. are frequently utilized in everyday practice. Some doctors even deviate from the theory of similimum, due to their over indulgence with ‘drug relationship’ protocols. When prescribing a drug based on its so-called complementary relationship to the earlier prescriptions, we forget to consider whether it is a similimum by totality of symptoms. Yet, we call it ‘classical’ homeopathy. When searching through the literature and authorities regarding drug relationships, it will be seen that no serious scientific studies have been done on this subject. Most of the drug relationships are proposed by empirical clinical observations of practitioners, and not corroborated by scientific studies or evidences. More over, practitioners who are not much bothered over this relationships between drugs swear that their experiences prove otherwise. Some homeopaths prescribe so-called inimical drugs even simultaneously or alternatingly, and get expected clinical results.
We have already seen during our previous deliberations that in homoeopathic potencies above 12C, there is no chance of drug molecules to exist. These preparations contain only hydrosomes or molecular imprints of constituent molecules of the drug substance subjected to potentization. Molecular imprints are only nanocavities formed by supra-molecular clustering of water and ethyl alcohol. Chemically, they contain only water and ethyl alcohol molecules. Even a given sample of homeopathic potency contains hundreds of types of individual imprints, representing the diverse types of molecules contained in the original drug substance. It is clear that they co-exist without disturbing or influencing each other in anyway, same time preserving their individual properties as molecular imprints of specific drug molecules.
1. This clearly indicates that highly potentized homoeopathic preparations cannot chemically interact with each other, since they contain no drug molecules. Obviously, they are not likely to engage in any mutual interaction within or outside the organism. They can never antidote or destroy each other.
2. Same time, the case of mother tinctures and preparations below 12c potencies may be totally different. They contain crude drug molecules, which can interact with each other due to their chemical properties. The concept of ‘drug relationships’ may be valid in the case of these low potencies. Low potencies may be more active than crude drugs, since they contain free molecules and ions.
3. Low potencies and mother tincture of a drug may antidote higher potencies of same drug, due to the interaction with the hydrosomes which act as counteractive complementary factors to each other.
4. Same way, low potencies and mother tinctures of a drug may antidote higher potencies of another drug that may contain similar constituent molecules, due to the interaction with the hydrosomes having counteractive complementary factors relationship. Obviously, drugs containing similar molecules may have more or less similar symptomatology during drug proving.
5. Higher potencies of a drug may antidote the physiological effects of low potencies and mother tinctures of same drug, due to the interaction with the hydrosomes acting as counteractive complementary factors.
6. Same way, higher potencies of a drug may antidote low potencies and mother tincture of another drug, that may contain similar constituent molecules, due to the interaction with the counteractive complementary factors contained in the higher potencies.
If there is similarity only between certain types of constituent molecules of two drugs, partial antodoting is possible. That means, molecules having configurational similarity only are subjected to antidoting by this way. Such drugs will have partially similar symptomatologies.
We should be aware of the possibility of dangerous chemical interactions that might result between the constituent drug molecules of different drugs, when we mix or administer two or more mother tinctures and low potency preparations together.